Analysis of Fetal Chromosome Abnormalities by Karyotpye

Prenatal screening is a crucial method employed during the fetal stage to detect and intervene early, thereby ensuring health of newborn babies. This approach serves enhance overall quality population mitigate severe consequences associated with birth defects. encompasses various techniques, including epidemiological investigations, imaging ultrasound, maternal blood screening, amniotic fluid by karotype technique. The process involves extracting chromosomes from cells present in fluid, followed cell culture hypotonic treatment. Subsequently, these are stained G-band examined under microscope. results obtained prenatal sample 121 patients, an average age 32 ± 6.69, indicated that 21% pregnant women had experienced miscarriage, 23.1% previously given malformed baby, 8.3% families genetic disease, 5% parents exhibited chromosomal abnormalities. Among 51 patients screened using Double test, 26.45% fetuses high risk defects, whereas Tripple test identified 9.09% 19 cases. Chromosome analysis cases revealed 15.7% abnormalities, Edwards syndrome accounting for 5.78%, Down 4.96%, abnormalities 3.30%, Patau 0.83%, Turner 0.83%. Age over 35 years (r = 0.08 OR 0.63), history miscarriage 0.05 1.38), family hereditary disease 0.04 parental mutations 0.01 1.08) were all found have strong positive correlation Additionally, correlations observed between ultrasound 0.22 5.48) 0.14 1.22).
 Amniocentesis, Karyotype, Chromosome, chromosome.